Category Archives: Haematology

Assessment of purpuric/petechial rashes

This was a BMJ module, based on this article. Steps in assessing purpuric/petechial rashes: Assess for acute illness and consider the possibility of meningococcal sepsis. If suspected, administer parenteral antibiotics and admit urgently. If meningococcus is not the suspected diagnosis, … Continue reading

Posted in Dermatology, Don't miss, Haematology | Leave a comment

B12 deficiency

Some notes from last week’s BMJ article: B12, when ingested, binds initially to R-protein, also known as haptocorrin; this keeps it stable in the acidic stomach environment. Binding with IF takes place in the duodenum. Haptocorrin levels can be reduced … Continue reading

Posted in Credits 2019, Haematology | Leave a comment

High-dose B12 therapy

The standard maintenance course of injectable B12 (after the two week loading period) is 1 mg every three months. Occasionally, I’ve come across a patient who finds that the effects of the injection wear off, and the symptoms of deficiency … Continue reading

Posted in Credits 2018, Haematology, Medication | Leave a comment

Antiplatelet therapy with anticoagulation therapy?

A BMJ article addressing an important and common question; in patients who have an indication for antiplatelet therapy plus an indication for anticoagulant therapy, should we give both or just one? In most cases, we should just give the anticoagulant, … Continue reading

Posted in Anticoagulants, Cardiovascular, Credits 2017, Haematology, Medication | Leave a comment

Haemolysis markers

Reticulocyte count up Reduced haptoglobin Raised LDH (BMJ Learning module on jaundice)

Posted in Haematology, Investigations, Lab results | Leave a comment

Easy bruising

I normally just use a full blood count to investigate easy bruising; I’ve ummed and ahhhed about getting a clotting screen as well, but it seems like overkill to me. However, the authors of an article in the latest BMJ … Continue reading

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Neutropenia

An old article; unearthed an old BMJ I’d saved but never got round to making notes on. BMJ 2014;349:g5340. Neutropenia is defined as a neutrophil count <1.5 x 10^9. It’s classified in increments of 0.5 (1 – 1.5 is mild, … Continue reading

Posted in Credits 2017, Haematology | Leave a comment